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US 11,371,025 B2Granted
Non-covalent loading of plant picovirus particles
AssigneeCase Western Reserve University
InventorsNicole Steinmetz, Daniel Popkin
Life of this patent
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Abstract
A method of non-covalently loading a plant picornavirus is described. The method includes contacting a plant picornavirus in solution with a molar excess of a cargo molecule to load the plant picornavirus with the cargo molecule, and then purifying the loaded plant picornavirus. Examples of cargo molecules include imaging agents, antitumor agents, and antiviral agents. Loaded plant picornaviruses prepared in this manner can be used to delivering cargo molecule to cells.
Claims20
A method of loading a plant picornavirus, comprising
- contacting a plant picornavirus in solution with a molar excess of at least about 500 fold of a cargo molecule to load the plant picornavirus with the cargo molecule, and
- purifying the loaded plant picornavirus.
Dependencies are inferred from the claim text.