Systems for producing cellular immunotherapeutics and methods of use thereof

A system for producing an immunotherapeutic product, the system comprising:

• a support comprising a first axis;
• a first module configured for processing cellular material associated with a disease of a patient comprising a fluid inlet port and a separate fluid outlet port;
• a second module configured for generating dendritic cells, the second module comprising a cell culture chamber comprising a fluid inlet port and a separate fluid outlet port, the cell culture chamber further comprising a second axis connecting the fluid inlet port and the fluid outlet port, wherein the second module is positioned on the support such that, when the system is in a functional orientation, the first axis is horizontal and the second axis is at an acute angle with respect to the first axis such that the fluid outlet port is retained above the fluid inlet port;
• a third module separately coupled to and in fluidic communication with each of the first and second modules, the third module comprising a first inlet port for fluidic communication with the first module and a separate second inlet port for fluidic communication with the second module such that the third module separately receives a flow of processed cellular material from the first module and separately receives a flow of generated dendritic cells from the second module, wherein the third module is configured to co-culture the processed cellular material and the generated dendritic cells to produce an immunotherapeutic product;
• and
• a control system, at least one pump, and at least one valve in operative arrangement and configured to automate and effect transfer of fluid from each of the first and second modules to the third module.