Magnetic nanoparticles for destroying pathological cells in an individual

A method of treatment of a tissue volume comprising pathological cells in an individual, comprising:

• administering to the individual an effective amount of a composition comprising magnetic nanoparticles to a first portion of a first tissue volume comprising pathological cells;
• and
• intentionally exposing the magnetic nanoparticles to radiation and exciting the magnetic nanoparticles by the radiation for at least a first time, the radiation not consisting of only an alternating magnetic field with a strength between 0.001 mT and 100 T and a frequency between 1 KHz and 1000 kHz, the radiation to which the magnetic nanoparticles are intentionally exposed and by which the magnetic nanoparticles are excited comprising at least one radiation property selected from the group i) to v) consisting of:
• i) a power between 0 and 109 Watt or Watt per cm3 tissue volume,
• ii) a frequency comprised between 0 and 104 KHz,
• iii) a power, strength, and/or frequency, which is/are sufficiently large to activate magnetic nanoparticles,
• iv) a power, strength, and/or frequency, which is/are kept below a threshold to avoid toxicity, and
• v) an exposure time of at least 10−6 seconds,
• wherein only said first portion of said first tissue volume comprising pathological cells is occupied by the magnetic nanoparticles upon administration of the composition to the individual, and
• wherein the treatment affects said first portion of said first tissue volume comprising pathological cells to which the magnetic nanoparticles were administered and at least one of:
• (a) a second portion of said first tissue volume comprising pathological cells to which the magnetic nanoparticles were not administered, said second portion of said first tissue volume being either exposed to the radiation or not exposed to the radiation;
• or
• (b) a second tissue volume comprising pathological cells, which is different from said first tissue volume and is not occupied by the magnetic nanoparticles, said second tissue volume being either exposed to the radiation or not exposed to the radiation.