Back to results
US 11,366,106 B2Granted
Modular point-of-care devices, systems, and uses thereof
AssigneeLabrador Diagnostics LLC
InventorsTammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
Life of this patent
Estimating the term…
Abstract
The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
Claims19
A system for performing an assay capable of detecting at least two analytes present in a sample, the device comprising:
- a cartridge comprising:
- a plurality of reagent units for storing cartridge reagents used to detect the at least two analytes;
- and
- a sample vessel configured to receive the sample;
- a plurality of assay assemblies, a first assay assembly of the plurality of assay assemblies comprising:
- an addressable assay unit configured to receive the sample and to receive a cartridge reagent from a reagent unit of the plurality of reagent units of the cartridge, wherein the addressable assay unit comprises an interior reaction site having thereon an immobilized binding reagent such that a reaction occurs within the assay unit that is configured to yield a detectable signal indicative of a presence of a first analyte in the sample;
- and
- an assembly tip in fluid communication with the addressable assay unit and comprising an opening, wherein the assembly tip is configured to place the addressable assay unit in fluid communication with the reagent unit of the plurality of reagent units or the sample vessel of the cartridge;
- an automated fluid transfer device configured to move the first assay assembly relative to the cartridge to selectively place the assembly tip of the first assay assembly into the sample vessel or into the reagent unit of the plurality of reagent units and to direct transfer of the sample or the cartridge reagent into the addressable assay unit via the assembly tip in a sequence according to a predetermined protocol for detecting the first analyte such that a reaction occurs within the addressable assay unit.
6 more elements
A system for performing an assay capable of detecting at least two analytes present in a sample, the system comprising:
- a cartridge comprising:
- a plurality of reagent units for storing cartridge reagents used to detect the at least two analytes;
- and
- a sample vessel configured to receive the sample;
- a plurality of assay assemblies, a first assay assembly of the plurality of assay assemblies comprising:
- an addressable assay unit for receiving a cartridge reagent from a reagent unit of the plurality of reagent units and the sample from the sample vessel, wherein the addressable assay unit comprises an interior reaction site having thereon an immobilized binding reagent such that a reaction occurs within the assay unit that is configured to yield a detectable signal indicative of a presence of a first analyte in the sample;
- and
- an assembly tip in fluid communication with the addressable assay unit and comprising an opening at a bottom of the assembly tip for transfer of the cartridge reagent and the sample from the cartridge into the addressable assay unit;
- and
- a reader assembly configured to receive the cartridge and the first assay assembly, the reader assembly comprising an automated fluid transfer device configured to move the first assay assembly relative to the cartridge and to selectively place the assembly tip of the first assay assembly into the sample vessel or into the reagent unit of the plurality of reagent units and to direct transfer of the sample or the cartridge reagent into the addressable assay unit via the assembly tip.
7 more elements
A system for performing an assay to detect whether an analyte is present in a sample, comprising:
- a cartridge comprising a housing defining a plurality of reagent units for storing cartridge reagents and a sample vessel configured to receive a sample;
- an assay assembly comprising an assay unit configured to run a reaction to detect whether an analyte is present in the sample, and a tubular tip in fluid communication with the assay unit;
- wherein the assay unit comprises an interior reaction site having an immobilized binding reagent such that when the analyte is present in the sample, and when the sample and at least one cartridge reagent from at least one reagent unit of the plurality of reagent units are transferred to the assay unit, a reaction occurs within the assay unit that produces a detectable signal indicative of the presence of the analyte in the sample;
- and
- an automated fluid transfer device having a head configured to couple to the assay assembly, wherein the automated fluid transfer device moves the assay assembly relative to the cartridge and directs transfer of the sample and the cartridge reagents from the cartridge into the assay unit through the tubular tip.
2 more elements
Dependencies are inferred from the claim text.