Apparatus and method for targeted biodetection using a phage carrying a single electron transistor
AssigneeNeuro-Kinesis Inc.
InventorJosh Shachar
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Abstract
A single electron transistor conjugated to a bacteriophage form a detectable probe where an RF signal identify the location of such probe at the site of specific biological matrix and provide a unique electronic signal such as a Coulomb Staircase and where such signal act as a diagnostic beacon and where such probe and a detector form a mesoscopic detector. The detector uses: a bioprobe containing the phage with its conjugated SET and the properties of the phage specificity; phage mobility within the biological environment and the phage ability to act as a carrier for the SET; and the SET's ultimate use as a beacon for the detection.
Claims20
An apparatus adapted for use for diagnostic testing of a biotarget in a biological environment at room temperature comprising:
- a phage including a linker, wherein the linker is configured to specifically conjugate to the biotarget;
- a nanoparticle attached to the phage;
- and
- a single electron transistor (SET) fabricated within the nanoparticle wherein the mesoscopic SET is configured to operate at a Coulomb blockade in the biological environment at room temperature.
A method for use for diagnostic testing of a biotarget in a biological environment at room temperature comprising:
- providing a phage including a linker to specifically conjugate to the biotarget;
- providing a nanoparticle with a single electron transistor (SET) fabricated within the nanoparticle where the SET is mesoscopic sized to operate at a Coulomb blockade in the biological environment at room temperature;
- and
- conjugating the nanoparticle with the single electron transistor (SET) with the phage through the linker to provide a mesoscopic electronic bioprobe.
The method of 10 further comprising forming a chain of multiple electronic bioprobes and where conjugating the nanoparticle with the single electron transistor (SET) with the phage through the linker to provide a mesoscopic electronic bioprobe comprises conjugating the chain through the linker to the phage provide a mesoscopic electronic bioprobe with multiple SETs.
Dependencies are inferred from the claim text.