Sulfur-containing polycyclic-hydroxypyridone carboxamide analog against HIV

A compound represented by the following formula (I) or a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

• wherein, Z is selected from S, SO and SO2;
• R0 is hydrogen, halogen, hydroxyl, a lower alkyl or a lower alkenyl, wherein each of the lower alkyl and the lower alkenyl is optionally interrupted by heteroatoms selected from —O—, —S—, —S(O)—, —S(O)2—, and —NR6—;
• —R6— is hydrogen, a lower alkyl, a cycloalkyl, a cycloalkyl lower alkyl, a lower alkenyl, a lower alkoxy, a aryl, an aryl lower alkyl, an aryloxy, an epoxy group, hydroxyl, an amino, and a phosphate group;
• Each Ra is independently hydrogen, halogen, a lower alkyl, a cycloalkyl, a cycloalkyl lower alkyl, a lower alkenyl, a lower alkoxy, an aryl, an aryl lower alkyl, an aryloxy, and an epoxy group;
• n is an integer of 0˜8;
• when n is 0, the ring is a five-membered ring;
• R1 is hydrogen, a lower alkyl, a cycloalkyl, a cycloalkyl lower alkyl, a lower alkenyl, a lower alkoxy, a aryl, a aryl lower alkyl, a aryloxy, and an epoxy group;
• R2 is hydrogen, a lower alkyl, a cycloalkyl, a cycloalkyl lower alkyl, a lower alkenyl, a lower alkoxy, an aryl, an aryl lower alkyl, an aryloxy, and an epoxy group;
• R3 and R3′ are each independently hydrogen, a lower alkyl, a cycloalkyl, a cycloalkyl lower alkyl, a lower alkenyl, a lower alkoxy, an aryl, an aryl lower alkyl, an aryloxy, an epoxy group, hydroxyl, an amino, and a phosphate group;
• R4 and R5 are each independently hydrogen or a lower alkyl, a cycloalkyl, a cycloalkyl lower alkyl, a lower alkenyl, a lower alkoxy, a aryl, an aryl lower alkyl, an aryloxy, and a heterocycle;
• or wherein R4 and R5 are combined together to form —W—, wherein W is [C(R6)2]L (L is an integer of 1˜4);
• each R6 is independently hydrogen, halogen, a lower alkyl, a cycloalkyl, a cycloalkyl lower alkyl, a lower alkenyl, a lower alkoxy, an aryl, an aryl lower alkyl, an aryloxy, and an epoxy group.