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US 11,364,495 B2Granted
Automated point-of-care devices for complex sample processing and methods of use thereof
OwnerAndrea Maria Dominic Pais, Rohan Joseph Alexander Paisinventors
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Abstract
The present invention provides methods and devices for simple, low power, automated processing of biological samples through multiple sample preparation and assay steps. The methods and devices described facilitate the point-of-care implementation of complex diagnostic assays in equipment-free, non-laboratory settings. The invention includes a microfluidic device comprising a reagent-dispensing unit, a sample extraction device and a specimen processing unit.
Claims19
A microfluidic device comprising a reagent-dispensing unit, wherein the reagent dispensing unit comprises:
- at a plurality of reagent pouches each comprising one or more reagents and a sealing layer;
- at least one fluidic well comprising an inlet conduit;
- an interface between the layer and the inlet conduit;
- at least one plunger and at least one sharp object or protrusion configured to rupture the sealing layer and deliver the one or more reagents into the microfluidic device when an actuation force is applied to a reagent pouch;
- and
- wherein at least one pouch of said plurality reagent pouches comprises at least two reagents comprising an aqueous reagent and a non-aqueous immiscible reagent packaged together in a single reagent pouch.
3 more elements
Dependencies are inferred from the claim text.