CHIKV RNA vaccines
AssigneeModernaTX, Inc.
InventorsGiuseppe Ciaramella, Eric Yi-Chun Huang, Kapil Bahl, Tal Zaks, Sunny Himansu, Sayda Mahgoub Elbashir
Life of this patent
Estimating the term…
Abstract
Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
Claims20
A method of inducing an immune response in a subject, the method comprising administering to the subject a Chikungunya virus (CHIKV) vaccine, comprising a ribonucleic acid (RNA) polynucleotide having an open reading frame encoding a CHIKV antigenic polypeptide comprising CHIKV E2 protein formulated in a lipid nanoparticle, in an amount effective to produce an antigen-specific immune response in the subject, wherein the lipid nanoparticle comprises a cationic lipid, a non-cationic lipid, a sterol, and a PEG-modified lipid.
A method of inducing an immune response in a subject, the method comprising administering to the subject a Chikungunya virus vaccine, comprising a messenger ribonucleic acid polynucleotide having an open reading frame encoding a E2 protein formulated in a lipid nanoparticle, in an amount effective to produce an antigen-specific immune response in the subject, wherein the lipid nanoparticle comprises 20-60 mol % ionizable cationic lipid, 5-25 mol % neutral lipid, 25-55 mol % cholesterol, and 0.5-5 mol % PEG-modified lipid.
Dependencies are inferred from the claim text.