Method for producing stable dispersible magnetic iron oxide single-core nanoparticles, stable dispersible magnetic iron oxide single-core nanoparticles and uses of same

A method for continuous production of dispersible, magnetic, single-core nanoparticles which do not assemble or aggregate in aqueous media, and which comprise iron oxide and have a diameter between 20 and 200 nm, comprising the steps of:

• a) preparing an aqueous solution comprising at least one base and at least one oxidant;
• b) preparing an aqueous solution comprising at least one iron salt and another iron salt which is different from the at least one iron salt and in a lower concentration;
• c) preparing an aqueous solution comprising at least one hydrophilic stabiliser;
• d) mixing the aqueous solution of a) and b) to form a mixture in a first micromixer, Fe(OH)2 being formed, which precipitates out of the solution and oxidises to form magnetic single-core nanoparticles comprising iron oxide;
• and
• e) mixing the mixture from d) with the aqueous solution from c) in a second micromixer, wherein the at least one hydrophilic stabiliser bonds to the iron oxide;
• wherein, in a) to e), the temperature is controlled from 10° C. to 200° C., and
• wherein the dispersible, magnetic, single-core nanoparticles which do not assemble or aggregate in aqueous media are produced;
• wherein the hydrophilic stabiliser comprises a substance selected from the group consisting of glycosidic flavonoids, quercetin, tannin, lignin, and bisphosphonate;
• wherein
• the hydrophilic stabiliser has at least one residue which bonds to the iron oxide;
• the at least one residue is linked to a hydrophilic polymer;
• and
• the at least one residue is selected from the group consisting of a phenol residue and a sugar residue.