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US 11,359,216 B2Granted
Microbial production of fatty diols
AssigneeGenomatica, Inc.
InventorsAndreas W. Schirmer, Noah Helman, Haibo Wang, Zhihao Hu, Vikranth Arlagadda, Alma Itzel Ramos-Solis, Elizabeth Clarke
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Abstract
The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
Claims9
A method for producing a 1,3 fatty diol comprising:
- (i) culturing a recombinant microorganism in a fermentation broth that comprises a simple carbon source, wherein said recombinant microorganism expresses;
- a nucleic acid sequences encoding a thioesterase having the classification EC 3.1.2.-, EC 3.1.1.5, or EC 3.1.2.14, wherein the thioesterase uses 3-hydroxyacyl-ACP as a substrate;
- and
- a nucleic acid sequence encoding a carboxylic acid reductase (CAR) having the classification EC 1.2.99.6;
- and
- (ii) isolating the 1.3 fatty diol from said fermentation broth.
3 more elements
Dependencies are inferred from the claim text.