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US 11,358,981 B2Granted
Compounds and methods for selective c-terminal labeling
AssigneeQuantum-Si Incorporated
InventorsHaidong Huang, Roger Nani, Omer Ad, Robert E. Boer
Life of this patent
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Abstract
The present disclosure relates to compounds and methods for selective C-terminal functionalization of peptides. In certain embodiments, the compounds have improved water-solubility, and are suitable for use in connection with peptide sequencing methodologies.
Claims16
A method of selective N-functionalization of a peptide, comprising reacting a plurality of peptides of Formula (XI):
- or a salt thereof, wherein each P independently is a peptide having an N-terminal amine, with a compound of Formula (XII):
- under conditions, comprising Cu2±, or a precursor thereof, and a buffer having a pH of 10-11;
- to obtain a plurality of ε-azido compounds of the Formula (XIIIb):
- or a salt thereof.
1 more element
Dependencies are inferred from the claim text.