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US 11,358,978 B2Granted
Process for preparing supramolecular platinum-based compounds
AssigneeAkamara Therapeutics, Inc.
InventorsNimish Gupta, Arindam Sarkar, Heeralal Bassi, Pradip Dutta
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Abstract
The present invention is in relation to the fields of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to improved methods for preparing lipid-conjugated platinum compounds with high purity and good yields. The present disclosure also relates to nanoparticles comprising lipid-conjugated platinum compounds with high drug loading efficiency for use in chemotherapy, and to methods for producing said nanoparticles.
Claims23
A method for preparing a cholesterol-conjugated platinum compound, the method comprising:
- a. reacting a cholesterol or a cholesterol derivative with a linker that is:
- to obtain,
- b. reacting the product obtained in step a) with a base that is LiOH, NaOH, KOH, RbOH, CsOH, Mg(OH)2, Ca(OH)2, Sr(OH)2, Ba(OH)2, an acid or any combination thereof to obtain a water-soluble salt of a cholesterol;
- and
- c. reacting the water-soluble salt of the cholesterol with a water-soluble platinum compound in a substantially aqueous solution to obtain the cholesterol-conjugated platinum compound as a precipitate;
- wherein the method provides a yield of >50% purity of >70% for the cholesterol-conjugated platinum compound.
3 more elements
Dependencies are inferred from the claim text.