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US 11,358,942 B2Granted
Substituted phenothiazines as proteasome activators
AssigneeBoard of Trustees of Michigan State University
InventorsJetze J. Tepe, Theresa A. Lansdell, Evert Njomen, Corey Lee Jones
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Abstract
The disclosure is directed to compounds of the formula (I): and uses of such compounds to treat neurodegenerative diseases and cancers.
Claims9
A compound of formula (I):
- wherein:
- A is alkylenyl;
- R1 is H;
- R2 is H;
- X is Cl;
- X1 is —S—;
- and
- X2 is S(O)2OH.
5 more elements
A method for reducing the accumulation of intrinsically disordered proteins in a subject, wherein the method comprises administering to the subject in need thereof a therapeutically effective amount of a compound of formula (I):
- wherein:
- A is alkylenyl;
- R1 is H;
- R2 is H;
- X is Cl;
- X1 is —S—;
- and
- X2 is S(O)2OH.
5 more elements
Dependencies are inferred from the claim text.