Selective potassium channel agonists
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorPeter Wipf
Life of this patent
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Abstract
Selective potassium channel agonists and methods of use thereof are disclosed. A compound, or a pharmaceutically acceptable salt thereof, having a formula I wherein R1 is H or optionally-substituted alkyl; R2 is optionally-substituted C1-C6 alkyl or optionally-substituted cyclopropyl; R3 and R4 are each independently H or optionally-substituted alkyl; R5 is H, optionally-substituted alkyl, acyl, or alkoxycarbonyl; R6 and R7 are each independently H, optionally-substituted alkyl, or R6 and R7 together form a carbocycle; R8 is substituted phenyl or optionally-substituted pyridinyl, provided that if R8 is substituted phenyl, then R2 is optionally-substituted cyclopropyl; and R9, R10 and R11 are each independently H, halo, or optionally-substituted alkyl.
Claims18
A compound, or a pharmaceutically acceptable salt thereof, having a formula I
- wherein:
- R1 is H or optionally-substituted alkyl;
- R2 is optionally-substituted cyclopropyl or optionally-substituted C1-C6 alkyl;
- R3 and R4 are each independently H or optionally-substituted alkyl;
- R5 is H, optionally-substituted alkyl, acyl, or alkoxycarbonyl;
- R6 and R7 are each independently H, optionally-substituted alkyl, or R6 and R7 together form a carbocycle;
- R8 is substituted phenyl or optionally-substituted pyridinyl, provided that if R8 is substituted phenyl, then R2 is optionally-substituted cyclopropyl;
- and
- R9, R10 and R11 are each independently H, halo, or optionally-substituted alkyl.
Dependencies are inferred from the claim text.