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US 11,357,872 B2Granted
Imaging neurotransmitters in vivo using functionalized carbon nanotubes
AssigneeThe Regents of the University of California
InventorsMarkita P. Del Carpio Landry, Linda A. Wilbrecht, Jackson Travis Del Bonis-O'Donnell, Abraham G. Beyene
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Abstract
Imaging based detection of changes in extracellular neurotransmitter concentration in living tissue is achieved using novel nanotube-based sensors. The sensors are functionalized, neurocompatible single-walled carbon nanotubes (SWNT) comprising an adsorbed neurotransmitter analyte selective polynucleotide.
Claims20
A method of imaging in mammalian brain tissue comprising:
- detecting changes in extracellular concentration of a neurotransmitter with a sensor located in live brain tissue in a brain slice or live mammal, the sensor comprising a functionalized, neurocompatible single-walled carbon nanotube (SWNT) comprising an adsorbed neurotransmitter-selective polynucleotide covalently bound to a neurocompatible polyethyleneglycol (PEG), wherein the polynucleotide is (GT)6, wherein the sensor exhibits detectably greater fluorescence in the presence of the neurotransmitter than in the absence thereof, and the sensor responds to the neurotransmitter on a millisecond time scale.
Dependencies are inferred from the claim text.