Compositions and methods for treating leber's hereditary optic neuropathy with NADH dehydrogenase proteins
AssigneeWuhan Neurophth Biotechnology Limited Company
InventorBin Li
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Abstract
Disclosed herein is a recombinant nucleic acid, comprising: a mitochondrial targeting sequence; a mitochondrial protein coding sequence, wherein said mitochondrial protein coding sequence encodes a polypeptide comprising a mitochondrial protein; and a 3′UTR nucleic acid sequence. Also disclosed is a pharmaceutical composition comprising the recombinant nucleic acid and a method of treating Leber's hereditary optic neuropathy (LHON) using the pharmaceutical composition.
Claims29
A recombinant nucleic acid, comprising:
- a mitochondrial targeting sequence;
- a mitochondrial protein coding sequence comprising a sequence that is at least 99% identical to SEQ ID NO:
- 11 or 12;
- and
- a 3′UTR nucleic acid sequence.
A recombinant nucleic acid, comprising a mitochondrial protein coding sequence, wherein said mitochondrial protein coding sequence encodes a polypeptide comprising a mitochondrial protein, wherein said mitochondrial protein coding sequence comprises a sequence that is at least 99% identical to SEQ ID NO:
- 11 or 12.
Dependencies are inferred from the claim text.