Cyanobacterial hosts and methods for producing chemicals
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsYousong Ding, Guang Yang
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Abstract
The present invention relates to recombinant cyanobacterial cells for the production of a chemical compound of interest. In particular, the present invention relates to genetic modifications that introduce one or more heterologous phosphopantetheinyl transferases (PPTases) into a cyanobacterial cell. These cells can, optionally, further comprise heterologous carrier protein and nucleic acid constructs that provide the cyanobacterial cells with the capability of producing chemicals of interest or compounds of interest, such secondary metabolites polyketides, nonribosomal peptides and their hybrids, the three major families of bioactive natural products, of cyanobacteria and other bacterial phyla, secondary metabolites analogs, and unnatural compounds.
Claims14
A recombinant cyanobacterial cell comprising (i) at least one nucleic acid construct encoding a heterologous phosphopantetheinyl transferase (PPTase) and (ii) at least one genetic modification that alters the expression of an endogenous PPTase.
Dependencies are inferred from the claim text.