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US 11,352,437 B2Granted
Conjugates enhancing total cellular accumulation
AssigneeDefence Therapeutics Inc.
InventorsSimon Beaudoin, Jeffrey Victor Leyton
Life of this patent
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Abstract
The present description relates to a conjugated compound comprising cholic acid (ChAc) or a variant thereof, the ChAc conjugated to a non-cell penetrating peptide comprising a nuclear localization sequence (NLS) conjugated to a compound of interest.
Claims14
A conjugated compound consisting essentially of an antibody covalently linked to a nuclear localization sequence (NLS) as set forth in SEQ ID NO:
- 1, said NLS covalently linked to cholic acid (ChAc).
Dependencies are inferred from the claim text.