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US 11,352,382 B2Granted
Mito-lonidamine, compositions and methods of use
AssigneesThe Medical College of Wisconsin, Inc., Aix-Marseille Universite
InventorsBalaraman Kalyanaraman, Micael J. Hardy, Olivier Ouari
Life of this patent
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Abstract
The present invention relates to mito-lonidamine compounds, compositions and methods of use in the treatment of cancer.
Claims19
A mito-lonidamine compound of formula I:
- wherein L is a linker selected from an C4-C20 alkyl, an amino acid, benzyl, C2-C20 alkene or PEG,
- and X is any halogen, 2,2,2-trifluoroacetic acid (TFA) or acetic acid.
A method of treating cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of a mito-lonidamine compound of formula I:
- wherein L is a linker selected from an C4-C20 alkyl, an amino acid, benzyl, C2-C20 alkene or PEG,
- and X is any halogen, 2,2,2-trifluoroacetic acid (TFA) or acetic acid.
A method of reducing cancer cell growth in a subject, the method comprising administering to the subject an effective amount of a mito-lonidamine compound of formula I:
- wherein L is a linker selected from an C4-C20 alkyl, an amino acid, benzyl, C2-C20 alkene or PEG,
- and X is any halogen, 2,2,2-trifluoroacetic acid (TFA) or acetic acid.
Dependencies are inferred from the claim text.