Phenoxymethyl derivatives

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• (1) RA is selected from the group consisting of
• i) C1-C6-alkyl,
• ii) cyano-C1-C6-alkyl,
• iii) C3-C8-cycloalkyl,
• iv) halo-C1-C6-alkoxy,
• v) halo-C1-C6-alkyl,
• vi) aryl substituted with RG, RG1 and RG2,
• vii) heterocycloalkyl substituted with RG, RG1 and RG2, and
• viii) heteroaryl substituted with RG, RG1 and RG2;
• and
• RB is selected from the group consisting of
• i) C1-C6-alkyl,
• ii) C3-C8-cycloalkyl,
• iii) C1-C6-alkylsulfonyl,
• iv) C3-C8-cycloalkylsulfonyl,
• v) C1-C6-alkylsulfonylamino,
• vi) C3-C8-cycloalkylsulfonylamino,
• vii) aminocarbonyl,
• ix) halogen,
• x) halo-C1-C6-alkoxy,
• xi) halo-C1-C6-alkyl,
• xii) heterocycloalkyl, and
• xiii) heteroaryl substituted with one H, C1-C6-alkyl, or trialkylsilyl-C1-C6-alkoxy-C1-C6-alkyl;
• or
• (2) RA is selected from the group consisting of
• i) cyano-C1-C6-alkyl,
• ii) C3-C8-cycloalkyl,
• iii) halo-C1-C6-alkoxy,
• iv) halo-C1-C6-alkyl,
• v) aryl substituted with RG, RG1 and RG2,
• vi) heterocycloalkyl substituted with RG, RG1 and RG2, and
• vii) heteroaryl substituted with RG, RG1 and RG2;
• and
• RB is cyano;
• and:
• RC and RC1 are independently selected from the group consisting of
• i) H,
• ii) C1-C6-alkyl,
• iii) C3-C8-cycloalkyl,
• iv) halo-C1-C6-alkoxy,
• v) halo-C1-C6-alkyl, and
• vi) halogen;
• or RB and RC together with the carbon atoms to which they are attached form a ring system selected from the group consisting of
• i) C3-C8-cycloalkyl substituted with one to two substituent independently selected from H, C1-C6-alkyl, halo-C1-C6-alkoxy, halo-C1-C6-alkyl and C3-C8-cycloalkyl,
• ii) heterocycloalkyl substituted with one to two substituent independently selected from H, C1-C6-alkyl, halo-C1-C6-alkoxy, halo-C1-C6-alkyl and C3-C8-cycloalkyl,
• iii) aryl substituted with one to two substituent independently selected from H, halogen, C1-C6-alkyl, halo-C1-C6-alkoxy, halo-C1-C6-alkyl and C3-C8-cycloalkyl, and
• iv) heteroaryl substituted with one to two substituent independently selected from H, halogen, C1-C6-alkyl, halo-C1-C6-alkoxy, halo-C1-C6-alkyl, and C3-C8-cycloalkyl;
• W is ring system A:
• RD1 is selected from the group consisting of
• i) H,
• ii) C1-C6-alkyl,
• iii) halo-C1-C6-alkoxy,
• iv) halo-C1-C6-alkyl, and
• v) C3-C8-cycloalkyl,
• RG is selected from the group consisting of
• i) H,
• ii) C1-C6-alkoxy,
• iii) C1-C6-alkoxy-C1-C6-alkylcarbonylamino-C1-C6-alkyl,
• iv) C1-C6-alkoxy-C1-C6-alkylcarbonyl(C1-C6-alkyl)amino-C1-C6-alkyl,
• v) C1-C6-alkoxycarbonyl,
• vi) C1-C6-alkyl,
• vii) C1-C6-alkylsulfonyl,
• viii) C3-C8-cyloalkylsulfonyl,
• ix) carboxy,
• x) cyano,
• xi) C3-C8-cycloalkyl,
• xii) C3-C8-cycloalkoxy,
• xiii) C3-C8-cycloalkylcarbonylamino-C1-C6-alkyl,
• xiv) C3-C8-cycloalkylcarbonyl(C1-C6-alkyl)amino-C1-C6-alkyl,
• xv) C1-C6-alkylcarbonylamino-C1-C6-alkyl,
• xvi) C1-C6-alkylcarbonyl(C1-C6-alkyl)amino-C1-C6-alkyl,
• xvii) halo-C1-C6-alkyl,
• xviii) halo-C1-C6-alkoxy,
• xix) halogen,
• xx) hydroxy,
• xxi) aminocarbonyl substituted on the nitrogen atom with RN and Ro,
• xxii) aminocarbonyl-C1-C6-alkoxy substituted on the nitrogen atom with RN and Ro,
• xxiii) heteroaryl substituted with one H, C1-C6-alkyl, C3-C8-cycloalkyl, alkyl, halo-C1-C6-alkoxy, benzyl or aryl, wherein benzyl and aryl are substituted with one to three substituents independently selected from H, C1-C6-alkyl, C3-C8-cycloalkyl, halo-C1-C6-alkyl and halo-C1-C6-alkoxy,
• xxiv) heterocycloalkyl-C1-C6-alkoxy substituted with one H, C1-C6-alkyl, C3-C8-cycloalkyl, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, benzyl or aryl, wherein benzyl and aryl are substituted with one to three substituents independently selected from H, C1-C6-alkyl, C3-C8-cycloalkyl, halo-C1-C6-alkyl and halo-C1-C6-alkoxy, and
• xxv) heterocycloalkyl-C1-C6-alkyl substituted with one H, C1-C6-alkyl, C3-C8-cycloalkyl, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, benzyl or aryl, wherein benzyl and aryl are substituted with one to three substituents independently selected from H, C1-C6-alkyl, C3-C8-cycloalkyl, halo-C1-C6-alkyl and halo-C1-C6-alkoxy;
• RG1 and RG2 are independently selected from the group consisting of
• i) H,
• ii) halogen,
• iii) C1-C6-alkyl,
• iv) C3-C8-cycloalkyl,
• v) halo-C1-C6-alkoxy, and
• vi) halo-C1-C6-alkyl;
• RN is selected from the group consisting of
• i) H,
• ii) C1-C6-alkoxy,
• iii) C1-C6-alkoxy-C1-C6-alkyl,
• iv) C1-C6-alkoxycarbonyl-C1-C6-alkyl,
• v) C1-C6-alkyl,
• vi) carboxy-C1-C6-alkyl,
• vii) C3-C8-cycloalkyl,
• viii) C3-C8-cycloalkyl-C1-C6-alkyl,
• ix) hydroxy-C1-C6-alkyl,
• x) phenyl, and
• xi) heteroaryl-C1-C6-alkyl;
• and
• RO is selected from the group consisting of
• i) H, and
• ii) C1-C6-alkyl;
• or RN and RO together with the nitrogen atom to which they are attached form a heterocycloalkyl.