Opioid receptor modulators and products and methods related thereto

A compound having the structure of Formula (I):

• or an isomer, racemate, or isotope, or pharmaceutically acceptable salt thereof, wherein:
• ring A is carbocycle or heterocycle;
• ring B is carbocycle or heterocycle;
• L is a ring C;
• ring C is a C3-C7 cycloalkyl or 3-7 membered heterocycloalkyl, substituted with 0-5 R7;
• R1 and R2 are each independently H, (C1-C6)alkyl, or C3-C7 cycloalkyl substituted with 0-5 halo;
• R3 and R4 are each independently H, (C1-C6)alkyl, (C1-C6)haloalkyl, carbocycle, or carbocyclealkyl;
• each R5 is independently —C(O)NR1R2, —NR1C(O)R2, —OC(O)R1, —C(O)OR1, —S(O)tNR1R2, —NR1S(O)tR2, —OH, —CN, halo, oxo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, or carbocycle;
• or R3 and one R5, together with the atoms to which they are connected, form a 5-7 membered heterocycle;
• each R6 is independently —C(O)NR1R2, —NR1C(O)R2, —OC(O)R1, —C(O)OR1, —S(O)tNR1R2, —NR1S(O)tR2, —OH, —CN, halo, oxo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, or carbocycle;
• each R7 is independently —C(O)NR1R2, —NR1C(O)R2, —OC(O)R1, —C(O)OR1, —S(O)tNR1R2, —NR1S(O)tR2, —OH, 13 CN, halo, oxo, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, or carbocycle;
• R8 is H or (C1-C6)alkyl;
• m is 1-5;
• n is 0-5;
• and
• t is 0.