Techniques for accelerating thermal equilibrium in a chromatographic column

A system, comprising:

• a storage for storing programming instructions and data;
• and
• a processor configured to:
• determine a desired set point for a temperature of a mobile phase exiting the liquid chromatography column at an outlet to accelerate thermal equilibrium for the liquid chromatography column by predicting a steady state temperature of the mobile phase at the outlet when the thermal equilibrium is reached and setting the steady state temperature as the desired set point;
• receive a measured temperature of the mobile phase exiting the liquid chromatography column at the outlet from an outlet temperature sensor;
• determine a difference between the received measured temperature of the mobile phase exiting the liquid chromatography column at the outlet and the desired set point;
• and
• based on the determined difference, control the heater to impart heat to the mobile phase to attempt to reach the desired set point.

A method performed by a processor, comprising:

• determining a desired set point for a temperature of a mobile phase exiting a liquid chromatography column at an outlet to accelerate thermal equilibrium for the liquid chromatography column by predicting a steady state temperature of the mobile phase at the outlet when the thermal equilibrium is reached and setting the steady state temperature as the desired set point;
• receiving a measured temperature of the mobile phase exiting the liquid chromatography column at the outlet from an outlet temperature sensor;
• determining a difference between the received measured temperature of the mobile phase exiting the liquid chromatography column at the outlet and the desired set point;
• and
• based on the determined difference, controlling a heater to impart heat to the mobile phase to attempt to reach the desired set point.