Bone substitute material
AssigneeGeistlich Pharma AG
InventorsClaudio Zihlmann, Michael Bufler
Life of this patent
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Abstract
A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material having a sintered CAP core and a closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core has a homogeneous coarse external surface comprising flat crystal platelets, which shows an enhanced osteogenic response, a method of promoting bone formation, bone regeneration and/or bone repair by implanting the biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material, and a process of preparation thereof.
Claims20
A biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material comprising a sintered CAP core and a closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, when viewed at a magnification of 3500×, has a homogeneously coarse external surface, and wherein the coarse external surface comprises flat epitactically grown nanocrystalline HAP crystal platelets.
An implant or prosthesis, the implant or prosthesis comprising a biphasic calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute material comprising a sintered CAP core and a closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, whereby the epitactically grown nanocrystals have the same size and morphology as human bone mineral, wherein the closed epitactically grown layer of nanocrystalline HAP deposited on the external surface of the sintered CAP core, when viewed at a magnification of 3500×, has a homogeneously coarse external surface, and wherein the coarse external surface comprises flat epitactically grown nanocrystalline HAP crystal platelets, and wherein the implant or prosthesis has a shape suitable for supporting bone formation, bone regeneration, bone repair and/or bone replacement at a defect site.
Dependencies are inferred from the claim text.