HMPV/hPIV3 mRNA vaccine composition
AssigneeModernaTX, Inc.
InventorsLori Panther, Christine Shaw, Igor Smolenov, Michael Watson, Tal Zaks
Life of this patent
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Abstract
Provided herein are vaccine composition comprising a chemically-modified messenger ribonucleic acid (mRNA) encoding a hMPV fusion (F) glycoprotein and a chemically-modified mRNA encoding a hPIV3 F glycoprotein formulated in a cationic lipid nanoparticle formulation, and related method for inducing an antigen-specific immune response.
Claims18
A method of inducing in a human subject human metapneumovirus (hMPV) and human parainfluenza virus 3 (hPIV3) neutralizing antibody titers, the method comprising administering to the human subject a vaccine composition comprising:
- (a) an mRNA comprising a nucleic acid sequence having at least 95% identity to the nucleic acid sequence of SEQ ID NO:
- 1;
- and
- (b) an mRNA comprising a nucleic acid sequence having at least 95% identity to the nucleic acid sequence of SEQ ID NO:
- 2, wherein the mRNA of (a) and the mRNA of (b) are in a lipid nanoparticle (LNP).
A method of inducing in a human subject human metapneumovirus (hMPV) and human parainfluenza virus 3 (hPIV3) neutralizing antibody titers, the method comprising administering to the human subject a vaccine composition comprising a 25 μg to 150 μg dose of messenger ribonucleic acid (mRNA) formulated in a lipid nanoparticle (LNP), wherein the mRNA comprises mRNA encoding an hMPV fusion (F) glycoprotein comprising the amino acid sequence of SEQ ID NO:
- 8 and mRNA encoding an hPIV3 F glycoprotein comprising the amino acid sequence of SEQ ID NO:
- 10,
- wherein the lipid nanoparticle comprises 45-55 mole percent (mol %) Compound I ionizable cationic lipid, 5-15 mol % DSPC, 35-40 mol % cholesterol, and 1-2 mol % DMG-PEG, and the geometric mean titer (GMT) of hMPV neutralizing antibodies and hPIV3 neutralizing antibodies induced in the subject is increased by at least 3-fold within 30 days of administering the vaccine composition, relative to baseline, and wherein Compound I has the formula:
Dependencies are inferred from the claim text.