Universal influenza vaccine
AssigneeCambridge Technologies, Inc.
InventorBen Hause
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Abstract
Immunogenic compositions for inducing a universal immune response to influenza, and particularly influenza A, by eliciting anti-neuraminidase antibodies which provide protection against heterologous influenza infection. Compositions comprising recombinant baculovirus expression vectors expressing neuraminidase in cultured insect cells dispersed in a pharmaceutically-acceptable carrier comprising insect cell culture media, and optional adjuvant. Methods of inducing immune responses against influenza, and particularly influenza A, by eliciting anti-neuraminidase antibodies in a host animal susceptible to infection.
Claims28
An immunogenic composition for inducing an immune response that mitigates clinical disease in swine from influenza after administration, said composition comprising recombinant baculovirus expression vectors in cultured insect cells dispersed in a pharmaceutically-acceptable carrier comprising insect cell culture media, optional adjuvant, said recombinant baculovirus expression vectors expressing a therapeutically effective amount of neuraminidase, said neuraminidase being associated with the cell membrane of said insect cells and/or baculovirus viral membrane surfaces in said composition and presented on the surfaces of said membranes.
Dependencies are inferred from the claim text.