Methods and compositions related to prostate cancer therapeutics
AssigneeThe Johns Hopkins University
InventorsJun Luo, Emmanuel S. Antonarakis, Changxue Lu, William Isaacs
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Abstract
Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with prostate cancer. Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with castration-resistant prostate cancer wherein such biological molecules and biomarkers comprise androgen-receptor splice variants that can be used to develop effective therapeutic regimens for prostate cancer patients. Disclosed herein are methods of using biological molecules and biomarkers related to androgen-receptor splice variants for assessing therapeutic resistance to drugs such as enzalutamide and abiraterone.
Claims18
A method comprising:
- determining the expression level of an androgen receptor variant 7 (AR-V7) in a sample from a prostate cancer patient by amplifying both full-length androgen receptor (“AR-FL”) and AR-V7 transcripts, wherein the sample is enriched for circulating tumor cells.
Dependencies are inferred from the claim text.