Production of frambinone by a recombinant fungal microorganism
AssigneeLesaffre Et Compagnie
InventorsAlexander Matthias Farwick, Thomas Desfougeres, Georges Pignede, Anaïs Roussel, Isabelle Mouly, Brieuc Morvan
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Abstract
The invention relates to a genetically modified fungal microorganism for the production of frambinone, the microorganism having the following characteristics: —the capacity to produce frambinone from tyrosine; and —a limited capacity or no capacity to break tyrosine down into tyrosol, p-hydroxyphenylacetaldehyde and/or p-hydroxyphenylacetate; and to the use of same for producing frambinone.
Claims6
A process for the production of frambinone comprising culturing a genetically modified fungal microorganism with a capacity to produce frambinone from tyrosine in a medium comprising tyrosine and a repressor of the path for breaking tyrosine down into tyrosol, p-hydroxyphenylacetaldehyde and/or p-hydroxyphenylacetate, and wherein the repressor is glutamate.
Dependencies are inferred from the claim text.