Modified mussel proteins, uses thereof and related compounds
AssigneeTechnische UniversitäT Berlin
InventorsMatthias Hauf, Nediljko Budisa, Florian Richter, Tobias Baumann, Tobias Schneider
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Abstract
Disclosed is a mussel adhesive protein including at least one photocaged 3,4-dihydroxyphenylalanine derivative residue including a protecting group on at least one hydroxyl residue of its catechol moiety. The photocaged 3,4-dihydroxyphenylalanine derivative residue replaces a naturally occurring amino acid and the protecting group can be cleaved from the 3,4-dihydroxyphenylalanine derivative residue by irradiation with UV light.
Claims10
A modified mussel adhesive foot protein-5 (fp-5), comprising a plurality of ortho-nitrobenzyl-3,4-dihydroxyphenylalanine residues, wherein each ortho-nitrobenzyl-3,4-dihydroxyphenylalanine residue comprises an ortho-nitrobenzyl group, wherein each ortho-nitrobenzyl-3,4-dihydroxyphenylalanine residue replaces a tyrosine residue and wherein the ortho-nitrobenzyl group can be cleaved from the ortho-nitrobenzyl-3,4-dihydroxyphenylalanine residue by irradiation with UV light,
- wherein the modified mussel adhesive fp-5 comprises an amino acid sequence being at least 95% identical to SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 11, SEQ ID NO:
- 12, or SEQ ID NO:
- 13.
Dependencies are inferred from the claim text.