Compounds as modulators of TLR2 signaling

A compound of Formula (A)

• or a tautomer, or a pharmaceutically acceptable salt of any of the foregoing, wherein
• indicates that the ring is saturated, partially unsaturated, or fully unsaturated;
• indicates that the
• is attached in either the E or Z configuration;
• G1 and G2 are each independently CRx;
• Rx is hydrogen or halogen;
• R1 is —OH;
• R2 is CHO;
• R3 is C1-C6alkoxy or halogen, wherein the C1-C6alkoxy of R3 is unsubstituted or substituted with one or more halogen;
• Y is —C(O)— or absent and R4 and R5 are each H,
• G3 is CH(X1—R6a), C(X1—R6a), N, N(X1—R6a), S, or O;
• G4 is CH(X2—R6b), C(X2—R6b), N, N(X2—R6b), S, or O;
• G5 is CH(X3—R6c), C(X3—R6c), N, N(X3—R6c), S, or O;
• G6 is CH(X4—R6d), C(X4—R6d), N, N(X4—R6d), S, O, or absent;
• G7 is N, C, or CH;
• wherein when G5 is N, at least one of (i), (ii), and (iii) applies:
• (i) at least one of G3, G4, and G6 is not CH;
• (ii) R4 and R5 come together to form —S—;
• and
• (iii) R3 is —OCH3 or halo;
• X1, X2, X3, and X4 are each independently absent,
• m is 1-6;
• R6a, R6b, R6c, and R6d are each independently hydrogen, C1-C6alkyl, C1-C6alkoxy, halo, —OH, —NRpRq, aryl, heterocyclyl, heteroaryl, —C1-C6alkyl-heterocyclyl, —OC(O)-heterocyclyl, —C(O)Rh, —S(O)2NRw1Rw2, —S(O)2Ry, or —NRz1S(O)2Rz2, wherein the C1-C6alkyl and C1-C6alkoxy of R6a, R6b, R6c, and R6d are each independently unsubstituted or substituted with one or more groups selected from the group consisting of cycloalkyl and halogen;
• the aryl and heteroaryl of R6a, R6b, R6c, and R6d are each independently unsubstituted or substituted with one or more groups selected from the group consisting of C1-C6alkyl, C1-C6alkoxy, —OH, and C1-C6alkyl-OH;
• and the heterocyclyl, —C1-C6alkyl-heterocyclyl, and —OC(O)-heterocyclyl of R6a, R6b, R6c, and R6d are each independently unsubstituted or substituted with one or more groups selected from the group consisting of C1-C6alkyl, C1-C6alkoxy, —OH, C1-C6alkyl-OH, ═O, and ═S;
• Rh is selected from the group consisting of H, C1-C6alkyl, C1-C6alkoxy, C3-C8cycloalkyl, and —NRrRs;
• Rp is H or C1-C6alkyl;
• Rq is C2-C3alkyl, —C(O)Rt, —C(O)ORu, or —C(O)NRv;
• Rr, Rs, Rw1, and Rz1 each independently selected from H and C1-C6alkyl;
• and
• Rt, Ru, Rv, Rw2, Ry, and Rz2 are each independently selected from H, C1-C6alkyl, unsubstituted or substituted C3-C8cycloalkyl, and unsubstituted or substituted heterocyclyl;
• or
• G5 is CH(X3—R6c) or C(X3—R6c), G6 is CH(X4—R6d) or C(X4—R6d), and R6c and R6d are taken together with the carbons to which they are attached to form a 6-membered aryl, a 6-membered heterocyclyl, or a 6-membered heteroaryl ring;
• wherein the 6-membered aryl, 6-membered heterocyclyl, and 6-membered heteroaryl rings are each independently unsubstituted or substituted;
• wherein no more than one of R6a, R6b, R6c, and R6d is C1-C6alkoxy or —OH;
• and
• wherein the compound is not a compound of Table 1X.