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US 11,344,627 B2Granted
Dendrimer-exosome hybrid nanoparticles as a delivery platform
AssigneeWisconsin Alumni Research Foundation
InventorsSeungpyo Hong, Sin-Jung Park
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Abstract
Described herein are hybrid nanoparticles that are exosomes loaded with one or more nanoparticle dendrimers. Also included are pharmaceutical compositions including the hybrid nanoparticles and methods of making the hybrid nanoparticles. Also described is a method of treating a human subject by administering to the human subject the above-described hybrid nanoparticles.
Claims9
A hybrid nanoparticle for targeting inflamed epithelia, comprising:
- an exosome loaded with one or more PAMAM dendrimers,
- wherein the exosome is isolated from human mesenchymal stem cells, wherein the exosome expresses the membrane proteins VLA-4, CD162, CXCR4, or a combination thereof, and wherein the exosome also expresses the exosome markers CD9,CD63, and CD81;
- and
- wherein the PAMAM dendrimer comprises a tumor-targeting agent and an anti-tumor agent, wherein the agents are bound via multivalent covalent interactions with the PAMAM dendrimer, and wherein the hybrid nanoparticle specifically targets inflamed epithelia.
1 more element
Dependencies are inferred from the claim text.