Combinations of mRNAs encoding immune modulating polypeptides and uses thereof
AssigneeModernaTX, Inc.
InventorsJoshua P. Frederick, Ailin Bai, Vladimir Presnyak, Stephen G. Hoge, Kerry Benenato, Iain McFadyen, Ellalahewage Sathyajith Kumarasinghe, Susannah Hewitt
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Abstract
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
Claims29
A method for treating cancer in a subject, comprising administering intratumorally to the subject a lipid nanoparticle (LNP) comprising:
- (i) a first mRNA comprising an open reading frame (ORF) encoding a human IL-23 polypeptide and (ii) a second mRNA comprising an ORF encoding a human IL-36 gamma polypeptide.
A method for treating cancer in a subject, comprising administering intratumorally to the subject a lipid nanoparticle (LNP) comprising:
- (i) a first mRNA comprising an open reading frame (ORF) encoding a human IL-23 polypeptide, (ii) a second mRNA comprising an ORF encoding a human IL-36 gamma polypeptide, and (iii) a third mRNA comprising an ORF encoding a human OX40L polypeptide.
Dependencies are inferred from the claim text.