Squalene epoxidase in the diagnosis and treatment of non-alcoholic fatty liver diseases
AssigneeThe Chinese University of Hong Kong
InventorsJun Yu, Dabin Liu, Chi-Chun Wong
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Abstract
The present invention provides a method for providing a diagnosis or prognosis of a non-alcoholic fatty liver disease (NAFLD) in a subject by detecting expression level of the Squalene Epoxidase (SQLE) gene. A kit and device useful for such methods are also provided. In addition, the present invention provides a method for treating NAFLD by suppressing SQLE gene expression or activity.
Claims6
A method for inhibiting progression of a non-alcoholic fatty liver disease (NAFLD) in a human subject, comprising orally administering to the human subject terbinafine in the amount of about 80 mg/kg bodyweight for about 8-9 weeks.
Dependencies are inferred from the claim text.