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US 11,339,378 B2Granted
Non-neuroinvasive viruses and uses thereof
AssigneesNorthwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College
InventorsGregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
Life of this patent
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Abstract
Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
Claims26
A variant herpesvirus or alphaherpes virus particle comprising at least one mutation in a UL37 protein, wherein said UL37 protein has at least 90% sequence identity to SEQ ID NO:
- 34 or SEQ ID NO:
- 35, wherein said at least one mutation is at one or more amino acid positions selected from the group consisting of Q403, E452, Q455, Q511, and R515, and wherein said virus particle exhibits reduced neuro-invasiveness relative to a virus particle lacking said mutation.
Dependencies are inferred from the claim text.