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US 11,339,217 B2Granted
Methods and agents for the diagnosis and treatment of hepatocellular carcinoma
AssigneeCircular Commitment Company
InventorsKuo-Jang Kao, Andrew T. Huang
Life of this patent
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Abstract
The present invention relates to methods of diagnosing and methods of treating hepatocellular carcinoma in a subject. The invention also relates to antagonists of PLVAP proteins, such as antibodies that specifically bind PLVAP proteins, as well as compositions and kits comprising antagonists of PLVAP proteins. The invention further relates to humanized antibodies that specifically bind PLVAP protein.
Claims7
An isolated nucleic acid encoding:
- i) an isolated polypeptide that specifically binds to SEQ ID NO:23 comprising:
- 1) an antibody variable domain that comprises:
- a) a CDR1 consisting of SEQ ID NO:5;
- b) a CDR2 consisting of SEQ ID NO:6;
- and
- c) a CDR3 consisting of SEQ ID NO:7;
- and
- 2) an antibody variable domain that comprises:
- d) a CDR1 consisting of SEQ ID NO:10;
- e) a CDR2 consisting of SEQ ID NO:11;
- and
- f) a CDR3 consisting of SEQ ID NO:12;
- or
- ii) an isolated polypeptide that specifically binds to SEQ ID NO:23 comprising:
- 1) an antibody variable domain that comprises:
- a) a CDR1 consisting of SEQ ID NO:15;
- b) a CDR2 consisting of SEQ ID NO:16;
- and
- c) a CDR3 consisting of SEQ ID NO:17;
- and
- 2) an antibody variable domain that comprises:
- d) a CDR1 consisting of SEQ ID NO:20;
- e) a CDR2 consisting of SEQ ID NO:21;
- and
- f) a CDR3 consisting of SEQ ID NO:22.
22 more elements
Dependencies are inferred from the claim text.