Compositions and methods for viral sensitization
AssigneeOttawa Hospital Research Institute and University of Ottawa
InventorsJean-Simon Diallo, Christopher Noyce Boddy, Mark Dornan, Ramya Krishnan, Rozanne Arulanandam, Fabrice Le Boeuf, Jeffrey Smith, Andrew Macklin
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Abstract
Provided are compounds of Formula (II) that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
Claims16
A method for enhancing or increasing viral production in cells comprising, administering a compound of Formula (V):
- or a pharmaceutically acceptable salt, or a stereochemically isomeric form thereof,
- wherein:
- X7 is H, substituted or unsubstituted aryl or heteroaryl;
- substituted or unsubstituted, linear or branched alkyl, alkenyl, or alkynyl;
- or substituted or unsubstituted cycloalkyl.
Dependencies are inferred from the claim text.