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US 11,339,120 B2Granted
Phenyl derivatives as cannabinoid receptor 2 agonists
AssigneeHoffmann-La Roche Inc.
InventorsOlivier Gavelle, Uwe Grether, Matthias Nettekoven, Stephan Roever, Mark Rogers-Evans, Didier Rombach
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Abstract
The invention relates to a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
Claims20
A compound of formula (I)
- wherein
- R1 is cyclopropyl, alkyl or haloazetidinyl;
- R2 is cyclopropylmethoxy, alkoxy, haloalkoxy, halopyridinyl, alkylpyrazolyl or halopyrrolidinyl;
- provided that at least one of R1 and R2 is cyclopropyl or cyclopropylmethoxy;
- R3 is —C(O)—NH—C(R4R5)—R6, —C(O)—R7 or R8;
- R4 and R5 are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkyl sulfonyl alkyl and alkyloxetanyl;
- or R4 and R5 together with the carbon atom to which they are attached form oxetanyl or dioxothiethanyl;
- R6 is aminocarbonyl, 5-methyl-1,2,4-oxadiazol-3-yl, hydroxyalkyl, thiazolyl, alkoxycarbonyl, carboxy, difluoroazetidinylcarbonyl, 5-amino-1,2,4-oxadiazol-3-yl, alkylaminocarbonyl or aminocarbonylalkyl;
- R7 is (aminocarbonyl)(difluoro)pyrrolidinyl or (aminocarbonyl)azaspiro[2.4]heptyl;
- and
- R8 is 3-alkyl-1,2,4-oxadiazol-5-yl or 5-alkyl-1,2,4-oxadiazol-3-yl;
- or a pharmaceutically acceptable salt or ester thereof.
9 more elements
Dependencies are inferred from the claim text.