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AssigneeUrodelia
InventorsNicole Rouquet, Patrick Frayssinet
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The present invention relates to a hydroxyapatite and/or tricalcium phosphate powder characterized in that it has undergone at least one sintering step at a temperature between 400° C. and 600° C. The invention also relates to a process for preparing such a powder, and to a composition comprising such a powder for use as an anti-tumour auto-vaccine and particularly in the treatment of the following pathological conditions: osteosarcoma, B or T lymphoma, mammary tumour, melanoma, haemangiosarcoma, mastocytoma, fibrosarcoma, brain tumours and schwannoma in a subject. The present invention also covers a drug combination comprising the composition of the invention and at least one second therapeutic agent, preferably an anti-tumour agent and/or a radiotherapeutic agent.
A method for treating B cell lymphomas in a subject comprising the step of administering to a subject suffering from B cell lymphomas an antitumor auto-vaccine composition, wherein the composition comprises a hydroxyapatite or tricalcium phosphate powder on which cytoplasmic proteins extracted from a tumor sample from said subject have been absorbed, said powder having a specific surface area SS≥m2/g and a particle size G≤200 μm, and being suspended in an injection liquid.
Dependencies are inferred from the claim text.