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US 11,338,027 B2Granted
Fusion comprising a cell penetrating peptide, a multi epitope and a TLR peptide agonist for treatment of cancer
AssigneeAmal Therapeutics SA
InventorsMadiha Derouazi, Elodie Belnoue
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Abstract
The present invention provides a complex for use in the prevention and/or treatment of cancer, the complex comprising a) a cell penetrating peptide, b) at least one antigen or antigenic epitope, and c) at least one TLR peptide agonist, wherein the components a)-c) are covalently linked. In particular, compositions for use in the prevention and/or treatment of cancer, such as a pharmaceutical compositions and vaccines are provided.
Claims44
A complex comprising:
- a) a cell penetrating peptide;
- b) at least three antigenic peptides;
- and
- c) at least one TLR peptide agonist,
- wherein the components a) c) are covalently linked, and
- wherein the at least three antigenic peptides comprise:
- (i) a peptide having an amino acid sequence according to SEQ ID NO:
- 95;
- (ii) a peptide having an amino acid sequence according to SEQ ID NO:
- 96;
- and
- (iii) a peptide having an amino acid sequence according to SEQ ID NO:
- 97.
10 more elements
Dependencies are inferred from the claim text.