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US 11,338,012 B2Granted
BRAF-based polypeptides for treatment of cancer
AssigneeUniversity of the Sciences
InventorsZhihong Wang, Zhijun Li, Amber Gunderwala
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Abstract
In one aspect, the invention provides a polypeptide derived from the dimer interface of BRAF, which is useful for treating various types of cancers. In certain embodiments, the polypeptide can be used to treat, prevent, and/or ameliorate a cancer such as but not limited to lung cancer.
Claims22
A method of treating or ameliorating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of:
- a polypeptide consisting of amino acid sequence TRHVNILLFM (SEQ ID NO:
- 1),
- a polypeptide consisting of amino acid sequence TRHVNILLFM (SEQ ID NO:
- 1) linked to a cell penetrating peptide, or
- a polypeptide consisting of amino acid sequence TRHVNILLFM (SEQ ID NO:
- 1) which is linked through a linker to a cell penetrating peptide.
3 more elements
Dependencies are inferred from the claim text.