Thermostable formulation of biologically active substances

A pharmaceutical formulation for antimicrobial treatment through application to skin or mucosa, comprising:

• a. an antimicrobiologically active lipid selected from the group consisting of glycerol monocaprate, glycerol monocaprylate,-glycerol monolaurate, propylene glycol monocaprate, propylene glycol monocaprylate, propylene glycol monolaurate, glycerol dicaprin, glycerol dicaprylate, glycerol dilaurate, glycerol tricaprin, glycerol tricaprylate, glycerol trilaurate, octylglycerol, monomyristin, monopalmitolein, monoolein, propylene glycol monocaprylate, propylene glycol monolaurate, and any combination thereof, in a concentration in the range from about 0.01 to about 5 wt %,
• b. one or more methoxypolyethylene glycol represented by the formula I:
• CH3—(O—CH2—CH2)n—H (I)
• wherein n is an integer in the range from 1 to 25, in an amount in the range from about 0.1 to about 60 wt %, and
• c. one or more polyoxyethylene-glyceride in an amount in the range from about 0.1 to about 60% having the formula (II):
• wherein R1, R2, and R3 are independently selected from the group consisting of C6 to C22 fatty acids, polyoxyethylene glycol (PEG), and hydrogen, provided that it contains at least one C6-C22 fatty acid and at least one PEG group.