Inhibitors and their uses
AssigneeUnited Kingdom Research and Innovation
InventorsAnne Bertolotti, Indrajit Das, Agnieszka Krzyzosiak, Adrien Rousseau, Kim Schneider, Anna Gudny Sigurdardottir
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Abstract
The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compounds of the invention include compounds having the formula IA or a pharmaceutically acceptable salt thereof, wherein R1a, R3a, R5a, Xa and Ya are as defined herein.
Claims15
A compound of 2-(3,4,5-trichlorobenzylidene)hydrazine-1-carboximidamide or a salt thereof.
A pharmaceutical composition comprising (E)-2-(3,4,5-trichlorobenzylidene)hydrazine-1-carboximidamide or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.