Murine parvovirus and uses thereof
AssigneesCentenary Institute of Cancer Medicine and Cell Biology, The University of Sydney
InventorsBen Roediger, Wolfgang Weninger, Shweta Tikoo
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Abstract
The present disclosure relates to a novel murine parvovirus, sequences encoded thereby, and applications therefor. In one embodiment the disclosure provides a method for detecting the presence of a parvovirus in a sample, comprising detecting one or more nucleic acids or polypeptides derived from the parvovirus, or antibodies against the parvovirus, in the sample. Also provided are vectors and host cells comprising sequences encoded by the parvovirus and related sequences. Also provided are animal models of kidney disease associated with infection by the parvovirus.
Claims7
A method for detecting the presence of a parvovirus in a sample, comprising detecting one or more nucleic acids or polypeptides derived from the parvovirus, or antibodies against the parvovirus, in the sample, wherein the parvovirus comprises:
- (i) a gene encoding a non-structural (NS1) protein comprising the amino acid sequence set forth in SEQ ID NO:
- 4, or an amino acid sequence comprising at least about 80% amino acid sequence identity thereto;
- (ii) a gene encoding a non-structural (NS2) protein comprising the amino acid sequence set forth in any one of SEQ ID NOs:
- 5 to 7, or an amino acid sequence comprising at least about 80% amino acid sequence identity thereto;
- (iii) a gene encoding a capsid protein (VP1) comprising the amino acid sequence set forth in SEQ ID NO:
- 8, or an amino acid sequence comprising at least about 80% amino acid sequence identity thereto;
- or
- (iv) the nucleotide sequence set forth in SEQ ID NO:
- 3 or a nucleotide sequence comprising at least about 70% sequence identity thereto.
Dependencies are inferred from the claim text.