Antiviral vaccines with improved cellular immunogenicity
AssigneesBeth Israel Deaconess Medical Center, Inc., Triad National Security, LLC
InventorsDan H. Barouch, Bette T. Korber, William M. Fischer
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Abstract
The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
Claims27
A nucleic acid molecule encoding a polypeptide comprising a sequence at least 99% identical to SEQ ID NO:12.
A nucleic acid molecule encoding a polypeptide comprising a sequence at least 99% identical to SEQ ID NO:10, or a nucleic acid molecule encoding a polypeptide comprising the sequence of SEQ ID NO:13.
Dependencies are inferred from the claim text.