Attenuated african swine fever virus vaccine
AssigneeThe Pirbright Institute
InventorsCharles Abrams, Ana-Luisa Reis, Chris Netherton, Linda Dixon, Dave Chapman, Pedro Sanchez-Cordon
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Abstract
The present invention provides an attenuated African Swine Fever (ASF) virus which lacks a functional version of the following genes: multigene-family 360 genes 9L, 10L, 11L, 12L, 13L and 14L; and multigene-family 505 genes 1R, 2R, 3R and 4R. The invention further provides an attenuated African Swine Fever (ASF) virus which Lacks a functional version of the DP148R gene. The present invention also provides a vaccine comprising such an attenuated virus and its use to prevent ASF. Further, the invention relates to intranasal administration of an attenuated ASF virus.
Claims16
A vaccine comprising an attenuated African Swine Fever (ASF) virus which lacks a functional version of the following genes:
- multigene-family 360 genes 9L, 10L, 11 L, 12L, 13L and 14L;
- and
- multigene-family 505 genes 1R, 2R, 3R and 4R.
A method of attenuating an African Swine Fever (ASF) virus, which comprises the step of partially or completely deleting, or interrupting the expression of, the following genes:
- multigene-family 360 genes 9L, 10L, 11 L, 12L, 13L and 14L;
- and
- multigene-family 505 genes 1R, 2R, 3R and 4R.
Dependencies are inferred from the claim text.