Compositions and methods for activating antigen presenting cells with chimeric poliovirus
AssigneeDuke University
InventorsSmita Nair, Michael Brown, Darell Bigner, Matthias Gromeier
Life of this patent
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Abstract
Chimeric poliovirus is capable of activating antigen presenting cells. The activation of the antigen presenting cells may be in vitro, ex vivo, or in vivo. The activated antigen presenting cells may be administered alone or with an antigen or vaccine. The activated antigen may be loaded in vitro or ex vivo with antigen to form antigen-loaded, activated, antigen presenting cells. These may be administered therapeutically. Therapeutic administration of antigen presenting cells may be used as an adjuvant to other therapies.
Claims34
An immunogenic composition comprising as separate components:
- an antigen selected from the group consisting of:
- an antigen of a bacterial pathogen, an antigen of a pathogenic parasite, an antigen of a non-polio virus, and a tumor antigen, wherein the antigen comprises a nucleic acid molecule;
- and
- an adjuvant comprising an infective chimeric poliovirus or RNA encoding the chimeric poliovirus.
An immunogenic composition comprising as separate components:
- an antigen selected from the group consisting of:
- an antigen of a bacterial pathogen, an antigen of a pathogenic parasite, an antigen of a non-polio virus, and a tumor antigen, wherein the antigen comprises a protein and the protein is bound to an antibody having binding specificity for the protein;
- and
- an adjuvant comprising an infective chimeric poliovirus or RNA encoding the chimeric poliovirus.
A kit comprising as separate components in separate containers:
- an antigen selected from the group consisting of:
- an antigen of a bacterial pathogen, an antigen of a pathogenic parasite, an antigen of a non-polio virus, and a tumor antigen, wherein the antigen comprises a nucleic acid molecule;
- and
- an adjuvant comprising an infective chimeric poliovirus or RNA encoding the chimeric poliovirus.
A kit comprising as separate components in separate containers:
- an antigen selected from the group consisting of:
- an antigen of a bacterial pathogen, an antigen of a pathogenic parasite, an antigen of a non-polio virus, and a tumor antigen wherein the antigen comprises a protein and the protein is bound to an antibody having binding specificity for the protein;
- and
- an adjuvant comprising an infective chimeric poliovirus or RNA encoding the chimeric poliovirus.
Dependencies are inferred from the claim text.