Acoustic blood separation processes and devices

An acoustophoretic device, comprising:

• an acoustic chamber configured to receive a flow of blood containing blood components;
• an ultrasonic transducer coupled to the acoustic chamber to generate an acoustic wave in an acoustic region of the acoustic chamber;
• a reflector across the acoustic chamber and opposite to the ultrasonic transducer and configured to reflect the acoustic wave to generate an acoustic field in the acoustic region;
• an inlet on a first side of the acoustic chamber;
• a filtrate outlet on a second side of the acoustic chamber, such that the acoustic region is between the inlet and the filtrate outlet;
• a concentrate extraction region below the acoustic region;
• and
• a lipid collection trap outlet above the acoustic region;
• wherein the acoustic field is configured to concurrently agglomerate blood cells and lipids into clumps that respectively settle towards the concentrate extraction region and rise toward the lipid collection trap outlet.