Hybrid membrane-coated nanoparticle composites and methods of making and using the same
AssigneePortland State University
InventorMarilyn Mackiewicz
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Abstract
Disclosed herein are embodiments of nanoparticle composites that comprise covalently coupled stabilizing agent molecules that improve stability of the nanoparticle composites and allow for tight packing of lipids and/or membranes. The nanoparticle composites can further comprise inhibition inhibitors and/or lipid components that interact to form a hybrid lipid bilayer membrane around the nanoparticle core. The nanoparticle composites can be coupled to drugs, targeting moieties, and imaging moieties. The nanoparticle composites can be used for in vivo drug deliver, disease diagnosis/treatment, and imaging.
Claims17
A nanoparticle composite, comprising:
- one or more lipid molecules that form a first layer of a hybrid membrane;
- one or more aggregation inhibitors that have a different structure from the one or more lipid molecules;
- one or more stabilizing agent molecules comprising a heteroatom group and an aliphatic chain comprising at least six carbon atoms, wherein the one or more aggregation inhibitors and the one or more stabilizing agent molecules form a second layer of the hybrid membrane;
- and
- a nanoparticle core encapsulated by the hybrid membrane, wherein the nanoparticle core has a triangular shape and comprises silver or an oxide thereof;
- and wherein (i) the nanoparticle core is covalently coupled to the one or more stabilizing agent molecules through the heteroatom group of the one or more stabilizing agent molecules such that the second layer of the hybrid membrane surrounds the nanoparticle core and the first layer of the hybrid membrane surrounds the second layer of the hybrid membrane.
Dependencies are inferred from the claim text.