Methods and compositions for treatment of Gaucher Disease via modulation of C5a receptor
AssigneeChildren's Hospital Medical Center
InventorManoj Kumar Pandey
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Abstract
Disclosed are compositions and methods for the reduction of C5a mediated immune inflammation. The methods, in various aspects, may include the step of administering a C5aR antagonist to a subject in need of such treatment. In one aspect, the subject in need may have a lysosomal acid storage disease. Therapeutic kits and articles of manufacture are also disclosed.
Claims19
A method of treating a lysosomal storage disease in an individual in need thereof, comprising administering a C5aR antagonist to said individual, said individual having one or more clinical signs selected from hepatosplenomegaly, anemia, thrombocytopenia, bone defects, or a combination thereof.
A method of treating Gaucher's disease in an individual in need. thereof, comprising administering an A8Δ71-73 peptide to said individual, said individual having one or more clinical signs selected from hepatosplenomegaly anemia, thrombocytopenia, bone defects, or a combination thereof.
Dependencies are inferred from the claim text.