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US 11,324,743 B2Granted
Treatment for the non alcoholic steatohepatitis and fibrosis
AssigneeMetabolys
InventorsGabriel Baverel, Gérard Moinet
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I) or their enantiomers, diastereoisomers thereof and the addition salts thereof with pharmaceutically acceptable bases or acids, for use for the prevention or treatment, preferably treatment, of NASH.
Claims13
A method for the treatment of NASH comprising the administration to a person in need thereof of a therapeutically effective amount of a compound of formula (I):
- wherein
- R1 represents:
- a group —C(O)CR4R5CR6R7C(O)OH;
- or
- a —(CH2)4C(O)OH group;
- m represents an integer ranging from 0 to 8;
- R2 represents:
- a C6 to C10 aryl group optionally substituted;
- or
- 5 to 10-membered heteroaryl group optionally substituted;
- R3, identical or different, represent:
- an alkyl, linear or branched, C1 to C5;
- optionally substituted by a carbocycle group or by a heterocycle group, the carbocycle being in 5 to 10 members, saturated, partially unsaturated or aromatic, substituted or non-substituted, the heterocycle comprising 5 to 10 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and which may comprise 1, 2 or 3 heteroatoms, identical or different,
- R4, R5, R6 and R7, identical or different, represent:
- a hydrogen atom;
- an alkyl group, linear or branched, in C1 to C5;
- a 5, 6 or 7-membered carbocycle group saturated, partially insaturated or aromatic, non-substituted or substituted;
- or
- R4 and R5 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted;
- or
- R6 and R7 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted;
- or their enantiomers, diastereoisomers thereof and the addition salts thereof with pharmaceutically acceptable bases or acids.
19 more elements
The method for the treatment of fibrosis, comprising the administration to a person in need thereof of a therapeutically effective amount of a compound of formula (I):
- wherein
- R1 represents:
- a group —C(O)CR4R5CR6R7C(O)OH;
- or
- a —(CH2)4C(O)OH group;
- m represents an integer ranging from 0 to 8;
- R2 represents:
- C6 to C10 aryl group optionally substituted;
- or
- a 5 to 10-membered heteroaryl group optionally substituted;
- R3, identical or different, represent:
- an alkyl, linear or branched, C1 to C5;
- optionally substituted by a carbocycle group or by a heterocycle group, the carbocycle being in 5 to 10 members, saturated, partially unsaturated or aromatic, substituted or non-substituted, the heterocycle comprising 5 to 10 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and which may comprise 1, 2 or 3 heteroatoms, identical or different,
- R4, R5, R6 and R7, identical or different, represent:
- a hydrogen atom;
- an alkyl group, linear or branched, in C1 to C5;
- a 5, 6 or 7-membered carbocycle group saturated, partially unsaturated or aromatic, non-substituted or substituted;
- or
- R4 and R5 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted;
- or
- R6 and R7 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted;
- or their enantiomers, diastereoisomers thereof and the addition salts thereof with pharmaceutically acceptable bases or acids.
19 more elements
A method for the treatment of NASH comprising the administration to a person in need thereof of a therapeutically effective amount of a compound of formula (I):
- wherein
- R1 represents:
- a group —C(O)CR4R5CR5R7C(O)OH;
- or
- a —(CH2)4C(O)OH group;
- m represents an integer ranging from 0 to 8;
- R2 represents:
- a C6 to C10 aryl group optionally substituted;
- or
- a 5 to 10-membered heteroaryl group optionally substituted;
- R3, identical or different, represent:
- an alkyl, linear or branched, C1 to C5, optionally substituted by a carbocycle group or by a heterocycle group, the carbocycle being in 5 to 10 members, saturated, partially unsaturated or aromatic, substituted or non-substituted, the heterocycle comprising 5 to 10 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and which may comprise 1, 2 or 3 heteroatoms, identical or different;
- R4, R5, R6 and R7, identical or different, represent:
- a hydrogen atom;
- an alkyl group, linear or branched, in C1 to C5;
- a 5, 6 or 7-membered carbocycle group saturated, partially unsaturated or aromatic, non-substituted or substituted;
- or
- R4 and R5 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted;
- or
- R6 and R7 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted;
- or their enantiomers, diastereoisomers thereof and the addition salts thereof with pharmaceutically acceptable bases or acids.
18 more elements
A method for the treatment of fibrosis comprising the administration to a person in need thereof of a therapeutically effective amount of a compound of formula (I):
- wherein
- R1 represents:
- a group —C(O)CR4R5CR6R7C(O)OH;
- or
- a —(CH2)4C(O)OH group;
- m represents an integer ranging from 0 to 8;
- R2 represents:
- a C6 to C10 aryl group optionally substituted;
- or
- a 5 to 10-membered heteroaryl group optionally substituted;
- R3, identical or different, represent:
- an alkyl, linear or branched, C1 to C5;
- optionally substituted by a carbocycle group or by a heterocycle group, the carbocycle being in 5 to 10 members, saturated, partially unsaturated or aromatic, substituted or non-substituted, the heterocycle comprising 5 to 10 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and which may comprise 1, 2 or 3 heteroatoms, identical or different,
- R4, R5, R6 and R7, identical or different, represent:
- a hydrogen atom;
- an alkyl group, linear or branched, in C1 to C5;
- a 5, 6 or 7-membered carbocycle group saturated, partially unsaturated or aromatic, non-substituted or substituted;
- or
- R4 and R5 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted;
- or
- R6 and R7 form together with the carbon atom to which they are bonded a carbocycle with 5, 6 or 7 members, substituted or non-substituted;
- or their enantiomers, diastereoisomers thereof and the addition salts thereof with pharmaceutically acceptable bases or acids.
19 more elements
Dependencies are inferred from the claim text.