Application of PDCD4 as a therapeutic target for antidepressants and/or anxiolytics drugs
AssigneeShandong University
InventorsLining Zhang, Yuan Li, Qun Wang, Chun Guo, Faliang Zhu
Life of this patent
Estimating the term…
Abstract
The application of PDCD4 as a drug treatment target for anti-depression and/or anti-anxiety disorders has been proved by experimental research that the increase of PDCD4 is an important factor leading to depression in the process of stress; PDCD4 as a target to inhibit its expression or function can play a good antidepressant role, and has no effect on normal physiological state. Therefore, PDCD4 can be used as a target in the preparation and screening of antidepressant and/or anxiolytic drugs, which has a broad application prospect.
Claims5
A method for treating stress-induced depression in a person in need thereof, the method comprising:
- administering, to the person, an effective amount of an antidepressant drug which interferes with or inhibits the expression of a programmed cell death factor 4 (PDCD4) gene,
- wherein the drug includes siRNA having the nucleotide sequence according to SEQ ID NO:
- 5.
An antidepressant medicament comprising an effective amount of a drug which interferes with or inhibits the expression of the PDCD4 gene
- wherein the drug includes siRNA having the nucleotide sequence according to SEQ ID NO:
- 5.
A method for decreasing expression of a programmed cell death factor 4 (PDCD4) gene in a person in need thereof, the method comprising:
- administering, to the person, an effective amount of a drug which interferes with or inhibits the expression of a programmed cell death factor 4 (PDCD4) gene,
- wherein the drug includes siRNA having the nucleotide sequence according to SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.